Identification of motor and nonmotor wearing‐off in Parkinson's disease: Comparison of a patient questionnaire versus a clinician assessment
Identifieur interne : 003892 ( Main/Exploration ); précédent : 003891; suivant : 003893Identification of motor and nonmotor wearing‐off in Parkinson's disease: Comparison of a patient questionnaire versus a clinician assessment
Auteurs : Mark Stacy [États-Unis] ; Annette Bowron [Royaume-Uni] ; Mark Guttman [Canada] ; Robert Hauser [États-Unis] ; Kim Hughes [Royaume-Uni] ; Jan Petter Larsen [Norvège] ; Peter Lewitt [États-Unis] ; Wolfgang Oertel [Allemagne] ; Niall Quinn [Royaume-Uni] ; Kapil Sethi [États-Unis] ; Fabrizio Stocchi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-06.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Cognition (drug effects), Cognition (physiology), Cognition Disorders (etiology), Comparative study, Disability Evaluation, Female, Fluctuations, Human, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Movement Disorders (etiology), Nervous system diseases, Outcome Assessment (Health Care), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Questionnaire, Questionnaires, Retrospective Studies, Severity of Illness Index, motor fluctuations, wearing‐off.
- MESH :
- chemical , adverse effects : Levodopa.
- drug effects : Cognition, Motor Activity.
- drug therapy : Parkinson Disease.
- etiology : Cognition Disorders, Movement Disorders.
- physiology : Cognition, Motor Activity.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Levodopa.
- Activities of Daily Living, Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Questionnaires, Retrospective Studies, Severity of Illness Index.
Abstract
This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing‐off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing‐off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing‐off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing‐off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing‐off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing‐off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing‐off. All of these results were found to differ significantly. The mean number of wearing‐off symptoms reported by the 165 subjects indicating wearing‐off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20383
Affiliations:
- Allemagne, Canada, Italie, Norvège, Royaume-Uni, États-Unis
- Angleterre, Caroline du Nord, District de Giessen, Floride, Grand Londres, Géorgie (États-Unis), Hesse (Land), Michigan, Ontario
- Londres, Marbourg, Toronto
- Université de Toronto
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-06">2005-06</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="726">726</biblScope><biblScope unit="page" to="733">733</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C6D97AD0581B76D55FADC9BCFE8E0852DB0DE091</idno><idno type="DOI">10.1002/mds.20383</idno><idno type="ArticleID">MDS20383</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Cognition (drug effects)</term><term>Cognition (physiology)</term><term>Cognition Disorders (etiology)</term><term>Comparative study</term><term>Disability Evaluation</term><term>Female</term><term>Fluctuations</term><term>Human</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (drug effects)</term><term>Motor Activity (physiology)</term><term>Movement Disorders (etiology)</term><term>Nervous system diseases</term><term>Outcome Assessment (Health Care)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Questionnaire</term><term>Questionnaires</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>motor fluctuations</term><term>wearing‐off</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Questionnaires</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etude comparative</term><term>Fluctuation</term><term>Homme</term><term>Parkinson maladie</term><term>Questionnaire</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing‐off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing‐off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing‐off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing‐off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing‐off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing‐off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing‐off. All of these results were found to differ significantly. The mean number of wearing‐off symptoms reported by the 165 subjects indicating wearing‐off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Nord</li><li>District de Giessen</li><li>Floride</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Hesse (Land)</li><li>Michigan</li><li>Ontario</li></region><settlement><li>Londres</li><li>Marbourg</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name></region><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name><name sortKey="Lewitt, Peter" sort="Lewitt, Peter" uniqKey="Lewitt P" first="Peter" last="Lewitt">Peter Lewitt</name><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name></noRegion><name sortKey="Hughes, Kim" sort="Hughes, Kim" uniqKey="Hughes K" first="Kim" last="Hughes">Kim Hughes</name><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name></country><country name="Canada"><region name="Ontario"><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></region></country><country name="Norvège"><noRegion><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name></noRegion></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name></region></country><country name="Italie"><noRegion><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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